研究業績

​2020年

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells.

Kumagai S, Togashi Y, Sakai C, Kawazoe A, Kawazu M, Ueno T, Sato E, Kuwata T, Kinoshita T, Yamamoto M, Nomura S, Tsukamoto T, Mano H, Shitara K, Nishikawa H.

Immunity. 14;53(1):187-203 2020.

 

Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer.

Fujimori D, Kinoshita J, Yamaguchi T, Nakamura Y, Gunjigake K, Ohama T, Sato K, Yamamoto M, Tsukamoto T, Nomura S, Ohta T, Fushida S.

BMC Cancer. 20(1):1014. 2020.

 

Severe Jackknife-like Kyphosis Malformation in the Fetus of a Free-ranging Sika Deer (Cervus nippon).

Ayaka Hata, Yuto Suda, Midori Saeki, Tatsuki Shimamoto, Hisashi Yoshimura, Masami Yamamoto, Aki Fujiwara, Shinji Kamiya, Makoto Haritani.

Japanese Journal of Zoo and Wildlife Medicine 25(4):141-145 2020.

 

FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.

Norihiko Sasaki, Fujiya Gomi, Hisashi Yoshimura, Masami Yamamoto, Yoko Matsuda, Masaki Michishita, Hitoshi Hatakeyama, Yoichi Kawano, Masashi Toyoda, Murray Korc, Toshiyuki Ishiwata.

Cancers. 12(10):2976 2020.

 

Primary Lymphangiosarcoma of the Urinary Bladder in a Dog.

Masaki Michishita, Y. Ishizaki, Masaki Konnai, Yukino Machida, Rei Nakahira, Hitoshi Hatakeyama, Hisashi Yoshimura, Masami Yamamoto, Satoshi Soeta, Kazuhiko Ochiai, K. Misawa, Naoko Yugeta, Daigo Azakami.

Journal of Comparative Pathology. 179 31-35 2020.

 

Hepatic neuroendocrine carcinoma with metastases to the lymph nodes in a sika deer (Cervus nippon yakushimae).

Ritsu Shibata, Yukino Machida, Hitoshi Hatakeyama, Hisashi Yoshimura, Masami Yamamoto, Kazuhiko Ochiai, Kazuyoshi Uematsu, Masaki Michishita.

The Journal of veterinary medical science. 82(2) 193-196 2020.

 

Alien parasitic infections in the endangered Ryukyu long-furred rat (Diplothrix legata) on Amami-Oshima Island, Japan.

Toshihiro Tokiwa, Hisashi Yoshimura, Keiko Ito, Syun Chou, Masami Yamamoto.

Parasitology International. 76(102058) 2020.

 

2019年

Diffuse Pulmonary Meningotheliomatosis with Sarcomatous Transformation in a Shiba Dog.

M Michishita, A Fujiwara-Igarashi, S Suzuki, H Hatakeyama, Y Machida, H Yoshimura, M Yamamoto, D Azakami, K Ochiai, T Ishiwata, M Fujita.

Journal of comparative pathology. 171 1-5 2019.

 

Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture.

Yuuki Shichi, Norihiko Sasaki, Masaki Michishita, Fumio Hasegawa, Yoko Matsuda, Tomio Arai, Fujiya Gomi,  Junko Aida, Kaiyo Takubo, Masashi Toyoda, Hisashi Yoshimura, Kimimasa Takahashi, Toshiyuki Ishiwata

Scientific reports. 9(1) 10871-10871 2019.

 

Malignant rhabdoid tumor of the musk gland and systemic T-cell lymphoma in a masked palm civet (Paguma larvata).

Yukino Machida, Masaki Michishita, Hisashi Yoshimura, Takuya Kato, Shin-Ichi Hayama, Kimimasa Takahashi.

The Journal of veterinary medical science. 81(7) 975-979 2019.

 

Toxoplasma gondii infection in Amami spiny rat on Amami-Oshima Island, Japan.

Toshihiro Tokiwa, Hisashi Yoshimura (co-first author), Sayoko Hiruma, Yukie Akahori, Ayami Suzuki, Keiko Ito, Masami Yamamoto, Kazunori Ike.

International Journal for Parasitology: Parasites and Wildlife. 9 244-247 2019.

 

Expression and Roles of S100A4 in Anaplastic Cells of Canine Mammary Carcinomas.

Hisashi Yoshimura, Aya Otsuka, Masaki Michishita, Masami Yamamoto, Minori Ashizawa, Manami Zushi, Maiko Moriya, Daigo Azakami, Kazuhiko Ochiai, Yoko Matsuda, Toshiyuki Ishiwata, Shinji Kamiya, Kimimasa Takahashi.

Veterinary pathology. 56(3) 389-398 2019.

 

2018年

Established gastric cancer cell lines transplantable into C57BL/6 mice show fibroblast growth factor receptor 4 promotion of tumor growth.

Masami Yamamoto, Sachiyo Nomura, Akihiro Hosoi, Koji Nagaoka, Tamaki Iino, Tomohiko Yasuda, Tomoko Saito, Hirokazu Matsushita, Eiji Uchida, Yasuyuki Seto, James R Goldenring, Kazuhiko Kakimi, Masae Tatematsu, Tetsuya Tsukamoto.

Cancer science. 109(5) 1480 - 1492 2018.

 

H19 long non-coding RNA contributes to sphere formation and invasion through regulation of CD24 and integrin expression in pancreatic cancer cells.

Norihiko Sasaki, Masashi Toyoda, Hisashi Yoshimura, Yoko Matsuda, Tomio Arai, Kaiyo Takubo, Junko Aida, Toshiyuki Ishiwata.

Oncotarget. 9(78) 34719-34734 2018.

 

Pancreatic cancer stem cells: features and detection methods.

Toshiyuki Ishiwata, Yoko Matsuda, Hisashi Yoshimura, Norihiko Sasaki, Shunji Ishiwata, Naoshi Ishikawa, Kaiyo Takubo, Tomio Arai, Junko Aida.

Pathology oncology research : POR. 24(4) 797-805 2018.

 

Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis.

Hisashi Yoshimura, Yoko Matsuda, Masami Yamamoto, Masaki Michishita, Kimimasa Takahashi, Norihiko Sasaki, Naoshi Ishikawa, Junko Aida, Kaiyo Takubo, Tomio Arai, Toshiyuki Ishiwata.

Laboratory investigation; a journal of technical methods and pathology. 98(6) 814-824 2018.

 

Expression and role of long non-coding RNA H19 in carcinogenesis.

Hisashi Yoshimura, Yoko Matsuda, Masami Yamamoto, Shinji Kamiya, Toshiyuki Ishiwata.

Frontiers in Bioscience – Landmark. 23(4) 614-625 2018.

 

2017年

Pancreatic Colloid Carcinoma in an Elderly Cat.

K. Hagiwara, M. Michishita, H. Yoshimura, K. Ochiai, D. Azakami, T. Ishiwata, K. Takahashi.

JOURNAL OF COMPARATIVE PATHOLOGY. 157(4) 266-269 2017.

 

Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit.

Mio Ishimori, Masaki Michishita, Hisashi Yoshimura, Daigo Azakami, Kazuhiko Ochiai, Toshiyuki Ishiwata, Kimimasa Takahashi.

JOURNAL OF VETERINARY MEDICAL SCIENCE. 79(9) 1503-1506 2017.

 

Cutaneous Angiolymphoid Hyperplasia in a Dog.

M. Michishita, Y. Katori, H. Sasaki, R. D. Obara, R. Furumoto, M. Kato, R. Nakahira, H. Yoshimura, S. Soeta, T. Ishiwata, K. Takahashi.

JOURNAL OF COMPARATIVE PATHOLOGY. 157(1) 57-60 2017.

 

Pancreatic neuroendocrine carcinoma with exocrine differentiation in a young cat.

Masaki Michishita, Mariko Takagi, Takuya E. Kishimoto, Rei Nakahira, Takeshi Nogami, Hisashi Yoshimura, Hitoshi Hatakeyama, Daigo Azakami, Kazuhiko Ochiai, Kimimasa Takahashi.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. 29(3) 325-330 2017.

 

Polyglucosan bodies in the prostatic stromal smooth muscles of aged dogs.

Shinji Kamiya, Hisashi Yoshimura (co-first author), Keina Okada, Ayaka Yoshida, Yuki Fukuda, Masami Yamamoto, Satoshi Soeta, Kimimasa Takahashi.

HISTOLOGY AND HISTOPATHOLOGY. 32(5) 499-502 2017.

 

Nestin phosphorylation at threonines 315 and 1299 correlates with proliferation and metastasis of human pancreatic cancer.

Yoko Matsuda, Toshiyuki Ishiwata, Hisashi Yoshimura, Kazuya Yamahatsu, Toshinari Minamoto, Tomio Arai.

CANCER SCIENCE. 108(3) 354-361 2017.

 

TERATOMA OF THE OVARY IN A FREE-RANGING JAPANESE RACCOON DOG (NYCTEREUTES PROCYONOIDES VIVERRINUS).

Hisashi Yoshimura, Masami Yamamoto, Maiko Moriya, Tomohiko Endo, Natsuko Sugiura, Takuya Kato, Yoko Matsuda, Toshiyuki Ishiwata, Hiroshi Kajigaya, Shinji Kamiya.

JOURNAL OF ZOO AND WILDLIFE MEDICINE. 48(1) 265-268 2017.

 

Contribution of oral triamcinolone to treating proliferative and necrotising otitis externa in a 14-year-old Persian cat.

Yutaka Momota, Junya Yasuda, Nobuaki Arai, Masami Yamamoto, Hisashi Yoshimura, Mitsutaka Ikezawa, Shuji Suzuki, Kimimasa Takahashi, Toshinori Sako.

Journal of Feline Medicine and Surgery Open Reports. 3(1) 2055116917691175 2017.

 

Malignant Oestrogen-producing Teratoma in a Cat.

Y. Machida, M. Michishita, M. Wada, T. Hori, E. Kawakami, H. Yoshimura, K. Ohkusu-Tsukada, K. Taya, K. Takahashi.

JOURNAL OF COMPARATIVE PATHOLOGY. 156(2-3) 178-182 2017.

 

Oncocytic carcinoma of the salivary gland in a dog.

Rei Nakahira, Masaki Michishita, Misaki Kato, Yuki Okuno, Hitoshi Hatakeyama, Hisashi Yoshimura, Daigo Azakami, Kazuhiko Ochiai, Makoto Bonkobara, Kimimasa Takahashi.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. 29(1) 105-108 2017.

 

2016年

Nodular cutaneous mucinosis in a hypothyroid dog - a severe form of myxoedema .

Yutaka Momota, Masami Yamamoto, Hiroki Yoshimatsu, Nozawa Satoshi, Kae Shigihara, Akiko Yasuda, Noriyuki Hayakawa, Mitsutaka Ikezawa, Kenji Tani, Akihiro Mori, Toshinori Sako.

VETERINARY DERMATOLOGY. 27(1) 61 - 62 2016.

 

後腹膜腔への巨大な転移腫瘤を伴った機能性悪性セルトリ細胞腫の犬の1例(Functional Malignant Sertoli Cell Tumor with Massive Metastasis in the Retroperitoneum in a Dog)

山本 昌美, 吉村 久志, 木村 彩友子, 市野瀬 香鈴, 神谷 新司

日本獣医生命科学大学研究報告 (65) 34-38 2016.

 

Clinicopathological Features of 15 Occult and 178 Clinical Pancreatic Ductal Adenocarcinomas in 8339 Autopsied Elderly Patients.

Yoko Matsuda, Toshiyuki Ishiwata, Shinichi Yachida, Akemi Suzuki, Yuri Hamashima, Hideki Hamayasu, Hisashi Yoshimura, Naoko Honma, Junko Aida, Kaiyo Takubo, Tomio Arai.

PANCREAS. 45(2) 234-240 2016.

 

Mitotic index and multipolar mitosis in routine histologic sections as prognostic markers of pancreatic cancers: A clinicopathological study.

Yoko Matsuda, Hisashi Yoshimura, Toshiyuki Ishiwata, Hiroki Sumiyoshi, Akira Matsushita, Yoshiharu Nakamura, Junko Aida, Eiji Uchida, Kaiyo Takubo, Tomio Arai.

PANCREATOLOGY. 16(1) 127-132 2016.

 

Systemic Administration of Small Interfering RNA Targeting Human Nestin Inhibits Pancreatic Cancer Cell Proliferation and Metastasis.

Yoko Matsuda, Toshiyuki Ishiwata, Hisashi Yoshimura, Satoshi Yamashita, Toshikazu Ushijima, Tomio Arai

PANCREAS. 45(1) 93-100 2016.

 

2015年

Tetragomphius melis Infection of the Pancreas in Japanese Badger (Meles meles anakuma).

Hisashi Yoshimura, Yoko Matsuda, Masami Yamamoto, Tomohiko Endo, Hiroshi Kajigaya, Toshihiro Tokiwa, Toshiyuki Ishiwata, Shinji Kamiya.

JOURNAL OF NIPPON MEDICAL SCHOOL. 82(6) 264-265 2015.

 

Characterization of Spontaneous Mammary Tumors in Domestic Djungarian Hamsters (Phodopus sungorus).

H. Yoshimura, N. Kimura-Tsukada, Y. Ono, M. Michishita, K. Ohkusu-Tsukada, Y. Matsuda, T. Ishiwata, K. Takahashi.

VETERINARY PATHOLOGY. 52(6) 1227-1234 2015.

 

Salivary Gland Epithelial-Myoepithelial Carcinoma with High-Grade Transformation in a Dog.

T.E. Kishimoto, H. Yoshimura, N. Saito, M. Michishita, N. Kanno, K. Ohkusu-Tsukada, K. Takahashi.

JOURNAL OF COMPARATIVE PATHOLOGY. 153(2-3) 111-115 2015.

 

Multispectral Imaging of Pancreatic Mixed Acinar-neuroendocrine-ductal Carcinoma with Triple-immunoenzyme Staining.

Hisashi Yoshimura, Yoko Matsuda, Akira Matsushita, Yoshiharu Nakamura, Eiji Uchida, Toshiyuki Ishiwata.

JOURNAL OF NIPPON MEDICAL SCHOOL. 82(3) 122-123 2015.

 

Neuroendocrine Carcinoma of the Mammary Gland in a Dog.

R. Nakahira, M. Michishita, H. Yoshimura, H. Hatakeyama, K. Takahashi.

JOURNAL OF COMPARATIVE PATHOLOGY. 152(2-3) 188-191 2015.

 

Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-translational modification of heat shock protein HSPA8/HSC71.

Yoko Matsuda, Toshiyuki Ishiwata, Hisashi Yoshimura, Masahito Hagio, Tomio Arai.

CANCER LETTERS. 357(2) 602-611 2015.

 

Cellular Sources of Tenascin-C in Canine Mammary Carcinomas.

H. Yoshimura, M. Michishita, K. Ohkusu-Tsukada, Y. Matsuda, T. Ishiwata, Z. Naito, K. Takahashi.

VETERINARY PATHOLOGY. 52(1) 92-96 2015.

 

2014年

Molecular Mechanism of Gastric Carcinogenesis in Helicobacter pylori-Infected Rodent Models.

Toyoda T, Yamamoto M, Takasu S, Ogawa K, Tatematsu M, Tsukamoto T.

Diseases. 2(2) 168 - 186 2014.

 

Differences in Indicators of Malignancy Between Luminal Epithelial Cell Type and Myoepithelial Cell Type of Simple Solid Carcinoma in the Canine Mammary Gland.

H. Yoshimura, R. Nakahira, T. E. Kishimoto, M. Michishita, K. Ohkusu-Tsukada, K. Takahashi.

VETERINARY PATHOLOGY. 51(6) 1090-1095 2014.

 

Inhibition of fibroblast growth factor receptor 2 attenuates proliferation and invasion of pancreatic cancer

Yoko Matsuda,Hisashi Yoshimura (co-first author),Taeko Suzuki,Eiji Uchida,Zenya Naito,Toshiyuki Ishiwata

CANCER SCIENCE 105(9) 1212-1219 2014年9月

 

Simultaneous Detection of Different RNAs Using a Novel Branched DNA in situ Hybridization Method.

Hisashi Yoshimura, Yoko Matsuda, Yoko Kawamoto, Zenya Naito, Toshiyuki Ishiwata.

JOURNAL OF NIPPON MEDICAL SCHOOL. 81(2) 62-63 2014.

 

Aortic squamous metaplasia in a patient with aortoesophageal fistula secondary to thoracic aortic aneurysm: An autopsy case.

Yoko Matsuda, Hisashi Yoshimura, Yuh Fukuda, Koji Murai, Hiroshi Honma, Ryuji Ohashi, Zenya Naito, Toshiyuki Ishiwata.

PATHOLOGY INTERNATIONAL. 64(4) 173-177 2014.

 

Nestin delineates pancreatic cancer stem cells in metastatic foci of NOD/Shi-scid, IL-2γnull (NOG) mice.

Matsuda Y, Yoshimura H, Ueda J, Naito Z, Korc M, Ishiwata T.

American Journal of Pathology. 184(3) 674-685 2014.

 

Fibroblast growth factor receptor-2 IIIc as a novel molecular target in colorectal cancer.

Yoko Matsuda, Seiichi Shinji, Hisashi Yoshimura, Zenya Naito, Toshiyuki Ishiwata.

Current Colorectal Cancer Reports. 10(1) 20-26 2014年.

 

Proliferative Lesions of Intra-epidermal Cytokeratin CAM5.2-Positive Cells in Canine Nipples.

K. Yasuno, S. Nishiyama, R. Kobayashi, H. Yoshimura, K. Takahashi, T. Omachi, J. Katmiie, K. Shirota.

JOURNAL OF COMPARATIVE PATHOLOGY. 150(1) 18-26 2014年.

 

2013年

Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer.

Takeshi Toyoda, Tetsuya Tsukamoto, Masami Yamamoto, Hisayo Ban, Noriko Saito, Shinji Takasu, Liang Shi, Ayumi Saito, Seiji Ito, Yoshitaka Yamamura, Akiyoshi Nishikawa, Kumiko Ogawa, Takuji Tanaka, Masae Tatematsu.

BMC GASTROENTEROLOGY. 13 122 2013.

 

Phosphorylation of Thr(1495) of nestin in a mouse model of cerebral ischemia and reperfusion damage.

Yoko Matsuda, Go Suzuki, Teruo Kusano, Yoko Kawamoto, Hisashi Yoshimura, Akira Fuse, Hiroyuki Yokota, Zenya Naito, Toshiyuki Ishiwata.

PATHOLOGY INTERNATIONAL. 63(9) 448-456 2013.

 

Acinar Cell Cystadenoma of the Pancreas in a Cat.

H. Yoshimura, Y. Matsuda, Y. Kawamoto, M. Michishita, K. Ohkusu-Tsukada, K. Takahashi, Z. Naito, T. Ishiwata.

JOURNAL OF COMPARATIVE PATHOLOGY. 149(2-3) 225-228 2013.

 

The Roles and Molecular Mechanisms of Nestin Expression in Cancer with a Focus on Pancreatic Cancer.

Matsuda Y, Yoshimura H, Naito Z, Ishiwata T.

Journal of Carcinogenesis & Mutagenesis. S9(002) 2013年.

 

In Vivo Bioluminescence Imaging of Pancreatic Cancer Xenografts in NOG Mice.

Yoshimura H, Matsuda Y, Naito Z, Ishiwata T.

Journal of Carcinogenesis & Mutagenesis. S9(003) 2013.

 

Investigation of the roles of fascioliasis and food allergy in intrahepatic eosinophilic proliferative pylephlebitis in Japanese Black cattle.

Kazuki Kishida, Kozo Ohkusu-Tsukada, Makito Hori, Masaki Konnai, Chieko Abiko, Yoshikazu Suzuki, Yukito Yamanome, Hisashi Yoshimura, Masaki Michishita, Kimimasa Takahashi.

Veterinary Journal. 196(2) 160-166 2013.

 

Antitumor Effect of Bevacizumab in a Xenograft Model of Canine Hemangiopericytoma.

Masaki Michishita, Tatsuya Uto, Ryota Nakazawa, Hisashi Yoshimura, Kikumi Ogihara, Yuko Naya, Tsuyoshi Tajima, Daigo Azakami, Seigo Kishikawa, Toshiro Arai, Kimimasa Takahashi.

JOURNAL OF PHARMACOLOGICAL SCIENCES. 121(4) 339-342 2013.

 

Apocrine sweat gland ductal adenoma with sebaceous differentiation in a dog.

Masaki Michishita, Junki Yasui, Rei Nakahira, Hisashi Yoshimura, Kimimasa Takahashi.

Case Report in Veterinary Medicine. 2013(ID167923)

 

Squamous cell carcinoma with systemic metastases in a spotted seal (Phoca largha).

Michishita M, Torikai K, Yoshimura H, Terasawa F, Nakahira R, Ohkusu-Tsukada K, Takahashi K.

Japanese Journal of Zoo and Wildlife Medicine. 18(4) 129-132 2013.

 

Upregulation of Superoxide Dismutase Activity in the Intestinal Tract Mucosa of Germ-Free Mice.

Yuu Dobashi, Hisashi Yoshimura, Eriko Atarashi, Kimimasa Takahashi, Atsushi Tohei, Hiromi Amao.

JOURNAL OF VETERINARY MEDICAL SCIENCE. 75(1) 49-54 2013.

 

2012年

Ultra-high-resolution Images of Nestin and Vimentin in Pancreatic Carcinoma Cells Using 2 Novel Microscopy Systems.

Hisashi Yoshimura, Yoko Matsuda, Zenya Naito, Megumi Murase, Yoko Kawamoto, Toshiyuki Ishiwata

JOURNAL OF NIPPON MEDICAL SCHOOL. 79(6) 392-393 2012.

 

2011年

Characterization of spheres derived from canine mammary gland adenocarcinoma cell lines.

Masaki Michishita, Rui Akiyoshi, Hisashi Yoshimura, Takuo Katsumoto, Hitoshi Ichikawa, Kozo Ohkusu-Tsukada, Takayuki Nakagawa, Nobuo Sasaki, Kimimasa Takahashi.

RESEARCH IN VETERINARY SCIENCE. 91(2) 254-260 2011.

 

Cutaneous invasive micropapillary carcinoma of probable apocrine sweat gland origin in a cat.

Yukino Machida, Hisashi Yoshimura, Rei Nakahira, Masaki Michishita, Kozo Ohkusu-Tsukada, Kimimasa Takahashi.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. 23(4) 840-844 2011.

 

Appearance and distribution of stromal myofibroblasts and tenascin-C in feline mammary tumors.

Hisashi Yoshimura, Masaki Michishita, Kozo Ohkusu-Tsukada, Kimimasa Takahashi.

HISTOLOGY AND HISTOPATHOLOGY. 26(3) 297-305 2011.

 

Increased Presence of Stromal Myofibroblasts and Tenascin-C With Malignant Progression in Canine Mammary Tumors.

H. Yoshimura, M. Michishita, K. Ohkusu-Tsukada, K. Takahashi.

VETERINARY PATHOLOGY. 48(1) 313-321 2011.

 

2010年

Lipid-rich carcinoma in the mammary gland of a Djungarian hamster (Phodopus sungorus).

Hisashi Yoshimura, Norie Kimura, Rei Nakahira, Masaki Michishita, Kozo Ohkusu-Tsukada, Kimimasa Takahashi.

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION. 22(2) 305-309 2010.

 

2009年

Gastric carcinogenesis by N-Methyl-N-Nitrosourea is enhanced in db/db diabetic mice.

Nao Yoshizawa, Hirokazu Yamaguchi, Masami Yamamoto, Nobuyuki Shimizu, Chie Furihata, Masae Tatematsu, Yasuyuki Seto, Michio Kaminishi.

CANCER SCIENCE. 100(7) 1180 - 1185 2009.

 

2008年

Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice.

Takasu S, Tsukamoto T, Cao X, Toyoda T, Hirata A, Ban H, Yamamoto M, Sakai H, Yanai T, Masegi T, Oshima M, Tatematsu M.

Cancer Science. 99(12) 2356 - 64 2008.

 

Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activation in gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19-C2mE transgenic mice.

Shinji Takasu, Tetsuya Tsukamoto, Xue-Yuan Cao, Takeshi Toyoda, Akihiro Hirata, Hisayo Ban, Masami Yamamoto, Hiroki Sakai, Tokuma Yanai, Toshiaki Masegi, Masanobu Oshima, Masae Tatematsu.

CANCER SCIENCE. 99(12) 2356 - 2364 2008.

 

Effects of a single-dose administration of Bowman-Birk inhibitor concentrate on anti-proliferation and inhabitation of metastasis in M5076 ovarian sarcoma-bearing mice.

Noritaka Sakurai, Kazuyuki Suzuki, Yuki Sano, Teruyoshi Saito, Hisashi Yoshimura, Yukie Nishimura, Tomohiro Yano, Yasuyuki Sadzuka, Ryuji Asano.

MOLECULAR MEDICINE REPORTS. 1(6) 903-907 2008.

 

Connexin 43-dependent tumor-suppressing effect of the Bowman-Birk protease inhibitor on M5076 ovarian sarcoma-bearing mice.

Noritaka Sakurai, Kazuyuki Suzuki, Tetsuya Nagaoka, Teruyoshi Saito, Hisashi Yoshimura, Tomohiro Yano, Yasuyuki Sadzuka, Ryuji Asano.

MOLECULAR MEDICINE REPORTS. 1(5) 689-693 2008.

 

2007年

Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine.

Akihiro Hirata, Tetsuya Tsukamoto, Masami Yamamoto, Shinji Takasu, Hiroki Sakai, Hisayo Ban, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu.

ONCOLOGY REPORTS. 18(4) 755 - 761 2007.

 

Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).

Akihiro Hirata, Tetsuya Tsukamoto, Masami Yamamoto, Shinji Takasu, Hiroki Sakai, Hisayo Ban, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu.

CANCER SCIENCE. 98(8) 1164 - 1173 2007.

 

2006年

Susceptibility to colon carcinogenesis in C3H <-> C57BL/6 chimeric mice reflects both tissue microenvironment and genotype.

Tetsuya Tsukamoto, Masami Yamamoto, Hiroko Fukami, Akemi Yoshikawa, Hirold Sakai, Akihiro Hirata, Moriaki Kusakabe, Masae Tatematsu.

CANCER LETTERS. 239(2) 205 - 211 2006.

 

Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis.

Akihiro Hirata, Tetsuya Tsukamoto, Masarni Yamamoto, Hiroki Sakai, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu.

CANCER LETTERS. 238(2) 271 - 283 2006.

 

2005年

Intraperitoneal injection of D-galactosamine provides a potent cell proliferation stimulus for the detection of initiation activities of chemicals in rat liver.

Y Asaoka, H Sakai, N Takahashi, A Hirata, T Tsukamoto, M Yamamoto, T Yanai, T Masegi, M Tatematsu.

JOURNAL OF APPLIED TOXICOLOGY 25(6) 554 - 561 2005.

 

Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice.

T Iidaka, T Tsukamoto, Y Totsuka, A Hirata, H Sakai, N Shirai, M Yamamoto, K Wakabayashi, T Yanai, T Masegi, LA Donehower, M Tatematsu.

CANCER LETTERS. 217(2) 149 - 159 2005.

 

2004年

Detection of initiating and promoting activity of aminophenylnorharman with a five-week in vivo initiation assay.

Takeshi Iidaka, Hiroki Sakai, Tetsuya Tsukamoto, Masami Yamamoto, Norimitsu Shirai, Yukari Totsuka, Keiji Wakabayashi, Tokuma Yanai, Toshiaki Masegi, Masae Tatematsu.

Journal of Toxicologic Pathology. 17(1) 1 - 5 2004.

 

2003年

beta-catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas.

T Tsukamoto, M Yamamoto, N Ogasawara, T Ushijima, T Nomoto, H Fujita, T Matsushima, K Nozaki, XY Cao, M Tatematsu.

CANCER SCIENCE. 94(12) 1046 - 1051 2003.

 

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.

H Sakai, T Tsukamoto, M Yamamoto, N Shirai, T Iidaka, A Hirata, T Yanai, T Masegi, LA Donehower, M Tatematsu.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 129(6) 335 - 340 2003.

 

Gastric Carcinogenesis and intestinalization induced by N-methyl-N-nitrosourea in the Scenscence-Accelerated Mouse (SAMP3).

Yamamoto M, Tsukamoto T, Sakai H, Hirata A, Yanai T, Masegi T, Hirano K, Furihata C, Tatematsu M

Journal of Toxicologic Pathology 16(1) 33 - 9 2003.

 

2002年

Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity.

H Sakai, T Tsukamoto, M Yamamoto, K Kobayashi, H Yuasa, T Imai, T Yanai, T Masegi, M Tatematsu.

CANCER LETTERS. 188(1-2) 33 - 38 2002.

 

Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis.

N Shirai, T Tsukamoto, M Yamamoto, T Iidaka, H Sakai, T Yanai, T Masegi, LA Donehower, M Tatematsu.

CARCINOGENESIS. 23(9) 1541 - 1547 2002.

 

Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N '-nitro-N-nitrosoguanidine.

HY Maeng, DK Choi, M Takeuchi, M Yamamoto, M Tominaga, T Tsukamoto, M Tatematsu, T Ito, Y Sakaki, C Furihata.

JAPANESE JOURNAL OF CANCER RESEARCH. 93(9) 960 - 967 2002.

 

Dendritic cell appearance and differentiation during early and late stages of rat stomach carcinogenesis.

M Takeuchi, M Yamamoto, M Tatematsu, K Miki, Y Sakaki, C Furihata.

JAPANESE JOURNAL OF CANCER RESEARCH. 93(8) 925 - 934 2002.

 

Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea.

M Yamamoto, C Furihata, T Ogiu, T Tsukamoto, K Inada, K Hirano, M Tatematsu

CANCER LETTERS. 179(2) 121 - 132 2002.

 

Summation of initiation activities in the liver after partial hepatectomy.

H Sakai, T Tsukamoto, M Yamamoto, A Hirata, A Inagami, N Shirai, T Iidaka, T Yanai, T Masegi, M Tatematsu.

CANCER LETTERS. 176(1) 1 - 5 2002.

 

Tongue carcinogenic susceptibility of p53 deficient mice to methyl-n-amylnitrosamine.

Norimitsu Shirai, Tetsuya Tsukamoto, Masami Yamamoto, Takeshi Iidaka, Hiroki Sakai, Tokuma Yanai, Toshiaki Masegi, Lawrence A. Donehower, Masae Tatematsu.

Journal of Toxicologic Pathology. 15(4) 209 - 214 2002.

 

The effects of allyl alcohol-induced cell proliferation for detection of initiation activities of chemicals in rat liver.

Miwa Okamura, Hiroki Sakai, Naofumi Takahashi, Atsushi Inagami, Tetsuya Tsukamoto, Masami Yamamoto, Norimitsu Shirai, Takashi Iidaka, Tokuma Yanai, Toshiaki Masegi, Masae Tatematsu.

Journal of Toxicologic Pathology. 15(2) 95 - 102 2002.

 

Preneoplastic changes of stomach cancer - Mice, rats and Mongolian gerbils.

Masae Tatematsu, Tetsuya Tsukamoto, Masami Yamamoto.

Journal of Toxicologic Pathology. 15(2) 133 - 136 2002.

 

2001年

Differential effects of partial hepatectomy and carbon tetrachloride administration on induction of liver cell foci in a model for detection of initiation activity.

Sakai, H, Tsukamoto, T, Yamamoto, M, Shirai, N, Iidaka, T, Yanai, T, Masegi, T, Tatematsu, M

JAPANESE JOURNAL OF CANCER RESEARCH. 92 1018 - 1025 2001.

 

2000年

p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

M Yamamoto, T Tsukamoto, H Sakai, N Shirai, H Ohgaki, C Furihata, LA Donehower, K Yoshida, M Tatematsu.

CARCINOGENESIS. 21(10) 1891 - 1897 2000.

 

Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.

T Ushijima, M Yamamoto, M Suzui, T Kuramoto, Y Yoshida, T Nomoto, M Tatematsu, T Sugimura, M Nagao.

CANCER RESEARCH. 60(4) 1092 - 1096 2000.

 

Summation of initiation activities of low doses of the non-hepatocarcinogen 1,2-dimethylhydrazine in the liver after carbon tetrachloride administration.

H Sakai, T Tsukamoto, M Yamamoto, T Yanai, T Masegi, K Inada, H Nakanishi, M Tatematsu.

CANCER LETTERS. 148(1) 59 - 63 2000.

 

1999年

Effects of low dose catechol on glandular stomach carcinogenesis in BALB c mice initiated with N-methyl-N-nitrosourea.

K Kobayashi, K Inada, C Furihata, T Tsukamoto, Y Ikehara, M Yamamoto, M Tatematsu.

CANCER LETTERS. 139(2) 167 - 172 1999.

 

Rare mutations of p53, Ki-ras, and β-catenin genes and absence of K- sam and c-erbB-2 amplification in N-methyl-N'-nitro-N-nitrosoguanidine- induced rat stomach cancers.

Yoshikazu Hirayama, Kuniko Wakazono, Masami Yamamoto, Motoo Kitano, Masae Tatematsu, Minako Nagao, Takashi Sugimura, Toshikazu Ushijima, Toshikazu Ushijima.

Molecular Carcinogenesis. 25(1) 42 - 47 1999.

 

Development and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat large intestine.

Tetsuya Tsukamoto, Ken-Ichi Kozaki, Yoko Nishikawa, Masami Yamamoto, Hiroko Fukami, Manami Inoue, Keiji Wakabayashi, Masae Tatematsu.

Japanese Journal of Cancer Research. 90(7) 720 - 725 1999.

 

Strong expression of glutathione S-transferase placental form in early preneoplastic lesions and decrease with progression in hamster buccal pouch carcinogenesis.

K Iida, M Yamamoto, M Kato, K Yoshida, K Kurita, M Tatematsu.

CANCER LETTERS. 135(2) 129 - 136 1999.

 

Clonality of urogenital organs as determined by analysis of chimeric mice.

 

JH Lipschutz, H Fukami, M Yamamoto, M Tatematsu, Y Sugimura, M Kusakabe, GR Cunha.

CELLS TISSUES ORGANS. 165(2) 57 - 66 1999.

 

1998年

Involvement of dendritic cell response to resistance of stomach carcinogenesis caused by N-methyl-N '-nitro-N-nitrosoguanidine in rats.

M Oka, C Furihata, K Kitoh, M Yamamoto, M Tatematsu, M Ichinose, K Miki, T Ito, Y Sakaki, K Reske.

CANCER RESEARCH. 58(18) 4107 - 4112 1998.

 

Clonal analysis of urothelial carcinomas in C3H/HeN⇆BALB/c chimeric mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

Shinji Yamamoto, Masae Tatematsu, Masami Yamamoto, Hiroko Fukami, Shoji Fukushima.

Carcinogenesis. 19(5) 855 - 860 1998.

 

Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water.

Masae Tatematsu, Masami Yamamoto, Nobuyuki Shimizu, Akemi Yoshikawa, Hiroko Fukami, Michio Kaminishi, Takeshi Oohara, Atsushi Sugiyama, Tatsuo Ikeno.

Japanese Journal of Cancer Research. 89(2) 97 - 104 1998.

 

1997年

Dose-dependent induction of both pepsinogen-altered pyloric glands and adenocarcinomas in the glandular stomach of C3H mice treated with N-methyl-N-nitrosourea.

Masami Yamamoto, Chie Furihata, Yasunobu Fujimitsu, Toshio Imai, Ken-Ichi Inada, Hayao Nakanishi, Masae Tatematsu.

Japanese Journal of Cancer Research. 88(3) 238 - 244 1997.

 

Differentially expressed MHC class II-associated invariant chain in rat stomach pyloric mucosa with N-methyl-N'-nitro-N-nitrosoguanidine exposure.

Chie Furihata, Masashi Oka, Masami Yamamoto, Takashi Ito, Masao Ichinose, Kazumasa Miki, Masae Tatematsu, Yoshiyuki Sakaki, Konrad Reske.

Cancer Research. 57(8) 1416 - 1418 1997.

 

1996年

Monoclonal development of squamous cell carcinomas from polyclonal papillary or nodular hyperplasias in the forestomach of C3H/HeN↔BALB/c chimeric mice treated with N-methyl-N-nitrosourea or diethylnitrosamine.

Masae Tatematsu, Tsuneo Masui, Hiroko Fukami, Masami Yamamoto, Hayao Nakanishi, Ken Ichi Inada, Yasunobu Fujimitsu, Moriaki Kusakabe.

Carcinogenesis. 17(6) 1365 - 1371 1996.

 

Primary monoclonal and secondary polyclonal growth of colon neoplastic lesions in C3H/HeN ⇆ BALB/c chimeric mice treated with 1,2-dimethylhydrazine: Immunohistochemical detection of C3H strain-specific antigen and simple sequence length polymorphism analy.

Masae Tatematsu, Masae Tatematsu, Tsuneo Masui, Hiroko Fukami, Masami Yamamoto, Hayao Nakanishi, Ken Ichi Inada, Moriaki Kusakabe, Teruyo Sakakura.

International Journal of Cancer. 66(2) 234 - 238 1996.

 

Expression of hepatocyte growth factor, c-met and glutathione S-transferase-P messenger RNAs during rat chemically induced hepatocarcinogenesis.

T Imai, T Masui, KI Inada, H Nakanishi, M Yamamoto, M Tatematsu

RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS. I 517 - 522 1996.

 

Induction of MHC class II-associated invariant chain in rat stomach pyloric mucosa by N-methyl-N'-nitro-N-nitrosoguanidine analyzed by fluorescent differential display.

C Furihata, M Oka, M Ichinose, K Miki, M Yamamoto, M Tatematsu, T Ito, Y Sakaki.

RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS I 647 - 651 1996.

 

Clonal growth of large intestinal tumors.

M Tatematsu, H Fukami, M Yamamoto, K Inada, H Nakanishi, M Kusakabe.

RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS. I 131 - 137 1996.

 

Induction of glandular stomach cancers in mice treated with N-methyl-N-nitrosourea.

T Yamachika, M Yamamoto, K Inada, H Nakanishi, M Tatematsu.

RECENT ADVANCES IN GASTROENTEROLOGICAL CARCINOGENESIS. I 707 - 712 1996.

 

1994年

Clonal analysis of glandular stomach carcinogenesis in C3H HeN ↔ BALB c chimeric mice treated with N-methyl-N-nitrosourea.

Masae Tatematsu, Hiroko Fukami, Masami Yamamoto, Hayao Nakanishi, Tsuneo Masui, Noriaki Kusakabe, Teruyo Sakakura.

Cancer Letters. 83(1-2) 37 - 42 1994.

 

1993年

INDUCTION OF GLANDULAR STOMACH CANCERS IN C3H MICE TREATED WITH N-METHYL-N-NITROSOUREA IN THE DRINKING-WATER.

M TATEMATSU, M YAMAMOTO, H IWATA, H FUKAMI, H YUASA, N TEZUKA, T MASUI, H NAKANISHI.

JAPANESE JOURNAL OF CANCER RESEARCH. 84(12) 1258 - 1264 1993.